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Precision Medicine - Pharmacogenetics and Nutrigenomics
Background
❱ A new study finds that illness and death resulting from the wrong prescription, the wrong dose, skipped doses or new medication-related issues—otherwise known as “non-optimized medication therapy”—cost an estimated $528 billion a year. This represents 16 percent of total U.S. health care expenditures, according to research published in the Annals of Pharmacotherapy.
❱ Non- optimized medication therapy results in 275,689 deaths per year.
❱ Pain costs an estimated $560 billion to $635 billion annually in lost workdays, medical expenses, and other benefit costs. Pharmacogenetics tests guide optimal pain management.
❱ Americans are less than 5% of the world’s population but consume 50% of world’s medicines.
❱ 32% of adverse events leading to hospitalizations are due to medications.
❱ In the United States, an estimated 25,000 patients per year hospitalized as a result of adverse events associated with antidepressants. According to a study conducted by Mayo Clinic physicians, children who are treated without the benefit of individualized molecular genotyping have only a 60% chance of successful long-term treatment.
❱ In 2014, FDA warned of the risk of serious breathing problems in some children who are CYP2D6 ultra-rapid metabolizers.
Our Genetic Drug Counselors, Board Certified Pharmacists and Physicians collaborate to –
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Introduce pharmacogenomics and nutrigenomics for innovative personalized medicine and clinical practice.
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Order appropriate Pharmacogenetic (PGx) tests, interpret and consult prescribers and patients.
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Determine genetic variants and drug-gene interactions (DGIs) through interpretations of PGx test results and data.
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Avoid adverse events, reduce polypharmacy, avoid ineffective prescribing, avoid lengthy “trial and error” method to choose the appropriate medication, lower medication costs.
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Optimize cardiac (anticoagulants, anti-platelets and statins), pain (opioid and NSAID), antidepressant and ADHD medications.
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Manage population health by monitoring usage of drugs that are affected by human genetic make-up.
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Avoid patient sufferings and improve quality of life, promote healthy lifestyle with less or no medications, improve patient satisfaction.
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Avoid costly hospital readmission, improve Quality Metrics including MIPS, MACRA, STAR Ratings and HEDIS, increase access to care, increase provider experience, avoid litigations resulted from ineffective outcomes or adverse events.
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Employ numerous resources, including genotype-based drug dosing/prescribing guidelines, drug label with biomarker information, pharmacokinetics and pharmacodynamics drug-centric pathways and summaries of important pharmacogenetics associations.
Precision Medicine - Pharmacogenetics and Nutrigenomics
Precision Medicine is an innovative approach for disease treatment and prevention based on individual variability in genes, environment, and lifestyle. Precision Medicine utilizes pharmacogenetics (often referred as Pharmacogenomics) and nutrigenomics that involves a person's genetic makeup as it affects their response to medications. Utilizing the emerging approach of precision medicine and pharmacogenomics, we can predict treatment and prevention strategies more accurately to ensure that medications, herbal products and supplements are safe and effective. Our trained pharmacists in collaboration with medical providers order gene panel and assist both the provider and patient in reviewing the results and identifying significant pharmacogenomics markers that may affect patient outcomes. Pharmacists use clinical practice guidelines that enable the translation of genetic results into actionable prescribing decisions for specific medications. Using the pharmacogenetics test results as a tool to provide evidence-based recommendations and assess a patient's risk of genetic implications on their current drug regimen, pharmacists are committed to enhanced, personalized, and precise medication therapy management services.
Benefit from PGx Testing for Those who :
Benefit from PGx Testing for Those who :
Are on medications and/or initiating treatment with medication with FDA’s black box warnings that require/recommend PGx testing.
Had experienced severe adverse drug reactions or complications due to adverse drug events.
Require higher than standard dosages to achieve the desired therapeutic result.
Have history of cardiovascular or mental health disease or family history of thromboembolism.
Benefit from PGx Testing for Those who :
Are diagnosed with new conditions with no previous pharmacological treatments that can be compared or evaluated.
Are with a family history of a serious adverse drug reaction or known pharmacogenomics variant.
Have a history of poor medication compliance and adherence.
Needs guidance to select the right medication for the first time based on individual’s genetic makeup.
Have experienced pharmacotherapy failure, as defined by having multiple unsuccessful drug trials.
Have experienced unexpected or exaggerated response to medications.
Have chronic conditions with multiple drugs prescribed to minimize drug-drug interactions, risk of adverse reaction, and potentially reduce the number of drugs prescribed.
Benefit from our Pharmacogenomics and Nutrigenomics services –
Individuals
ACOs